The effect of inflammation on voriconazole trough concentrations in children
نویسندگان
چکیده
University of Groningen, University Medical Center Groningen, Department of Clinical Pharmacy and Pharmacology, Groningen, the Netherlands, Department of Mathematics and Computer Science, Eindhoven University of Technology, Eindhoven, the Netherlands, Department of Pharmacy, Section Pharmacotherapy and Pharmaceutical Care, University of Groningen, Groningen, the Netherlands, University of Groningen, University Medical Center Groningen, Department of Pediatrics (Infection/Immunology), Groningen, the Netherlands, and University of Groningen, University Medical Center Groningen, Department of Pediatrics (Oncology/Hematology), Groningen, the Netherlands
منابع مشابه
Inflammation is associated with voriconazole trough concentrations.
Voriconazole concentrations display a large variability, which cannot completely be explained by known factors. Inflammation may be a contributing factor, as inflammatory stimuli can change the activities and expression levels of cytochrome P450 isoenzymes. We explored the correlation between inflammation, reflected by C-reactive protein (CRP) concentrations, and voriconazole trough concentrati...
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BACKGROUND Voriconazole pharmacokinetic and pharmacodynamic data are lacking in children. METHODS Records at the Childrens Hospital Los Angeles were reviewed for children with > or =1 serum voriconazole concentration measured from 1 May 2006 through 1 June 2007. Information on demographic characteristics, dosing histories, serum concentrations, toxicity and survival, and outcomes was obtained...
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Neely et al [1] have studied the disposition of voriconazole in children suspected or proven to have a fungal infection. Although this is important, and the pharmacokinetic data are most welcome in this difficult-to-study population, the ability to link the drug concentrations observed to outcome is the critical issue for this study. A number of other investigators have linked measures of voric...
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Trough (predose) voriconazole concentrations in plasma and pulmonary epithelial lining fluid (ELF) of lung transplant recipients receiving oral voriconazole preemptive treatment were determined. The mean (± standard deviation [SD]) ELF/plasma ratio was 12.5 ± 6.3. A strong positive linear relationship was noted between trough plasma and ELF voriconazole concentrations (r(2) = 0.87), suggesting ...
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BACKGROUND Voriconazole concentrations display a large variability, which cannot completely be explained by known factors. We investigated the relationships of voriconazole concentration with patient-specific variables and concomitant medication to identify clinical factors affecting voriconazole clearance. METHODS A retrospective chart review of voriconazole trough concentration, laboratory ...
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